| Sanford USDMedical CenterAcute care hospital · Sioux Falls | ★★★★★ | ★★★★★ | Yes | 545 | Compare Sanford USDMedical Center |
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| Va Black Hills Healthcare SystemVA hospital · Fort Meade | ★★★★★ | ★★★★★ | Yes | 420 | Compare Va Black Hills Healthcare System |
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| Sioux Falls Va Medical CenterVA hospital · Sioux Falls | ★★★★★ | ★★★★★ | Yes | 270 | Compare Sioux Falls Va Medical Center |
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| Avera Heart Hospital Of South DakotaAcute care hospital · Sioux Falls | ★★★★★ | ★★★★★ | Yes | 53 | Compare Avera Heart Hospital Of South Dakota |
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| Avera St Benedict Health Center - CAHCritical access hospital · Parkston | ★★★★★ | Not rated | No | 25 | Compare Avera St Benedict Health Center - CAH |
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| Avera McKennan Hospital & University Health CenterAcute care hospital · Sioux Falls | ★★★★★ | ★★★★★ | Yes | 505 | Compare Avera McKennan Hospital & University Health Center |
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| Avera St LukesAcute care hospital · Aberdeen | ★★★★★ | ★★★★★ | Yes | 109 | Compare Avera St Lukes |
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| Brookings Health SystemAcute care hospital · Brookings | ★★★★★ | ★★★★★ | Yes | 49 | Compare Brookings Health System |
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| Sanford Medical Center AberdeenAcute care hospital · Aberdeen | ★★★★★ | ★★★★★ | Yes | 48 | Compare Sanford Medical Center Aberdeen |
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| Monument Health Spearfish HospitalAcute care hospital · Spearfish | ★★★★★ | ★★★★★ | Yes | 44 | Compare Monument Health Spearfish Hospital |
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| Avera Queen Of PeaceCritical access hospital · Mitchell | ★★★★★ | ★★★★★ | Yes | 25 | Compare Avera Queen Of Peace |
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| Community Memorial HospitalCritical access hospital · Redfield | ★★★★★ | Not rated | Yes | 25 | Compare Community Memorial Hospital |
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| Coteau Des Prairies Health Care SystemCritical access hospital · Sisseton | ★★★★★ | Not rated | Yes | 25 | Compare Coteau Des Prairies Health Care System |
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| Monument Health Rapid City HospitalAcute care hospital · Rapid City | ★★★★★ | ★★★★★ | Yes | 417 | Compare Monument Health Rapid City Hospital |
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| Avera Sacred Heart HospitalAcute care hospital · Yankton | ★★★★★ | ★★★★★ | Yes | 144 | Compare Avera Sacred Heart Hospital |
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| Prairie Lakes Healthcare System, IncAcute care hospital · Watertown | ★★★★★ | ★★★★★ | Yes | 81 | Compare Prairie Lakes Healthcare System, Inc |
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| Avera St Mary's HospitalAcute care hospital · Pierre | ★★★★★ | ★★★★★ | Yes | 60 | Compare Avera St Mary's Hospital |
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| Huron Regional Medical CenterCritical access hospital · Huron | ★★★★★ | ★★★★★ | Yes | 25 | Compare Huron Regional Medical Center |
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| South Dakota Human Services CenterPsychiatric hospital · Yankton | Not rated | Not rated | No | 133 | Compare South Dakota Human Services Center |
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| Pine Ridge IHS HospitalAcute care hospital · Pine Ridge | Not rated | Not rated | Yes | 45 | Compare Pine Ridge IHS Hospital |
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| Dunes Surgical HospitalAcute care hospital · Dakota Dunes | Not rated | ★★★★★ | No | 38 | Compare Dunes Surgical Hospital |
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| Sioux Falls Specialty HospitalAcute care hospital · Sioux Falls | Not rated | ★★★★★ | No | 33 | Compare Sioux Falls Specialty Hospital |
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| PHS Indian Hospital At RosebudAcute care hospital · Rosebud | Not rated | Not rated | Yes | 29 | Compare PHS Indian Hospital At Rosebud |
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| Black Hills Surgical Hospital LLCAcute care hospital · Rapid City | Not rated | ★★★★★ | No | 26 | Compare Black Hills Surgical Hospital LLC |
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| Avera Gregory HospitalCritical access hospital · Gregory | Not rated | Not rated | Yes | 25 | Compare Avera Gregory Hospital |
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| Fall River Hospital - CAHCritical access hospital · Hot Springs | Not rated | Not rated | Yes | 25 | Compare Fall River Hospital - CAH |
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| Freeman Medical Center - CAHCritical access hospital · Freeman | Not rated | Not rated | Yes | 25 | Compare Freeman Medical Center - CAH |
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| Madison Regional Health SystemCritical access hospital · Madison | Not rated | Not rated | Yes | 25 | Compare Madison Regional Health System |
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| Milbank Area Hospital/Avera HealthCritical access hospital · Milbank | Not rated | Not rated | Yes | 25 | Compare Milbank Area Hospital/Avera Health |
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| Mobridge Regional Hospital - CAHCritical access hospital · Mobridge | Not rated | Not rated | Yes | 25 | Compare Mobridge Regional Hospital - CAH |
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| Monument Health Sturgis HospitalCritical access hospital · Sturgis | Not rated | Not rated | Yes | 25 | Compare Monument Health Sturgis Hospital |
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| Sanford Chamberlain Medical CenterCritical access hospital · Chamberlain | Not rated | Not rated | Yes | 25 | Compare Sanford Chamberlain Medical Center |
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| Sanford Hospital Webster - CAHCritical access hospital · Webster | Not rated | Not rated | Yes | 25 | Compare Sanford Hospital Webster - CAH |
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| Sanford Vermillion Medical CenterCritical access hospital · Vermillion | Not rated | Not rated | Yes | 25 | Compare Sanford Vermillion Medical Center |
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| St Michael's Hospital - CAHCritical access hospital · Tyndall | Not rated | Not rated | Yes | 25 | Compare St Michael's Hospital - CAH |
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| Winner Regional Healthcare Center - CAHCritical access hospital · Winner | Not rated | Not rated | Yes | 25 | Compare Winner Regional Healthcare Center - CAH |
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| Avera Dells Area Hospital - CAHCritical access hospital · Dell Rapids | Not rated | Not rated | Yes | 23 | Compare Avera Dells Area Hospital - CAH |
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| Marshall County Healthcare Center - CAHCritical access hospital · Britton | Not rated | Not rated | Yes | 20 | Compare Marshall County Healthcare Center - CAH |
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| Wagner Community Memorial Hospital - CAHCritical access hospital · Wagner | Not rated | Not rated | Yes | 20 | Compare Wagner Community Memorial Hospital - CAH |
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| Avera Flandreau Hospital - CAHCritical access hospital · Flandreau | Not rated | Not rated | Yes | 18 | Compare Avera Flandreau Hospital - CAH |
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| Hans P Peterson Memorial Hospital - CAHCritical access hospital · Philip | Not rated | Not rated | Yes | 18 | Compare Hans P Peterson Memorial Hospital - CAH |
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| LifescapeChildren's hospital · Sioux Falls | Not rated | Not rated | No | 18 | Compare Lifescape |
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| Monument Health Lead-Deadwood HospitalCritical access hospital · Deadwood | Not rated | Not rated | Yes | 18 | Compare Monument Health Lead-Deadwood Hospital |
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| Platte Health CenterCritical access hospital · Platte | Not rated | Not rated | Yes | 17 | Compare Platte Health Center |
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| Avera Weskota Memorial Medical Center - CAHCritical access hospital · Wessington Springs | Not rated | Not rated | Yes | 16 | Compare Avera Weskota Memorial Medical Center - CAH |
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| Community Memorial HospitalCritical access hospital · Burke | Not rated | Not rated | Yes | 16 | Compare Community Memorial Hospital |
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| Bennett County Hospital And Nursing Home - CAHCritical access hospital · Martin | Not rated | Not rated | Yes | 14 | Compare Bennett County Hospital And Nursing Home - CAH |
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| Bowdle Hospital - CAHCritical access hospital · Bowdle | Not rated | Not rated | Yes | 12 | Compare Bowdle Hospital - CAH |
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| Faulkton Area Medical CenterCritical access hospital · Faulkton | Not rated | Not rated | Yes | 12 | Compare Faulkton Area Medical Center |
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| Monument Health Custer HospitalCritical access hospital · Custer | Not rated | Not rated | Yes | 12 | Compare Monument Health Custer Hospital |
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| Pioneer Memorial Hospital - CAHCritical access hospital · Viborg | Not rated | Not rated | Yes | 12 | Compare Pioneer Memorial Hospital - CAH |
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| Avera Hand County Memorial Hospital And ClinicCritical access hospital · Miller | Not rated | Not rated | Yes | 11 | Compare Avera Hand County Memorial Hospital And Clinic |
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| Douglas County Memorial Hospital-CAHCritical access hospital · Armour | Not rated | Not rated | Yes | 11 | Compare Douglas County Memorial Hospital-CAH |
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| Sanford Canton-Inwood Medical Center - CAHCritical access hospital · Canton | Not rated | Not rated | Yes | 11 | Compare Sanford Canton-Inwood Medical Center - CAH |
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| Sanford Clear Lake Medical CenterCritical access hospital · Clear Lake | Not rated | Not rated | Yes | 10 | Compare Sanford Clear Lake Medical Center |
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| Eagle Butte Indian Health Service HospitalCritical access hospital · Eagle Butte | Not rated | Not rated | Yes | 8 | Compare Eagle Butte Indian Health Service Hospital |
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| Avera Missouri River Health CenterCritical access hospital · Gettysburg | Not rated | Not rated | Yes | 7 | Compare Avera Missouri River Health Center |
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| Avera De Smet Memorial Hospital - CAHCritical access hospital · De Smet | Not rated | Not rated | Yes | 6 | Compare Avera De Smet Memorial Hospital - CAH |
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| Same Day Surgery Center LLCAcute care hospital · Rapid City | Not rated | Not rated | No | 6 | Compare Same Day Surgery Center LLC |
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| Eureka Community Health Services - CAHCritical access hospital · Eureka | Not rated | Not rated | Yes | 4 | Compare Eureka Community Health Services - CAH |
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| Landmann Jungman Memorial Hospital CorporationRural emergency hospital · Scotland | Not rated | Not rated | Yes | 1 | Compare Landmann Jungman Memorial Hospital Corporation |
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